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DP Lyle Shane McKnight DP Lyle Shane McKnight

The Myth of the Untraceable Poison

Is there such a thing as an untraceable poison? DP Lyle unpacks the medical myths and forensic realities behind poison detection in dead bodies. From screening tests to cunning killers, learn how the science of toxicology shapes great crime fiction.

By DP Lyle


One of the most common questions I get from writers is: Is there a poison that can’t be found in a corpse? The answer is No. And Yes.

Much depends on the state of the corpse when it is found. If severely decayed or completely skeletonized, the ME and the forensic toxicologist have their hands tied. Mostly. There are some toxins, such as the heavy metals (Mercury, Lead, and Arsenic are common ones), that can be found in bones and hair. But most toxins can’t be found in corpses that are severely decayed or simply bones.

In a more or less intact body, your villain can still get away with the murder by poison. That is, until your clever sleuth figures out that something is amiss and solves the crime.

The first thing your murderer must consider is how to make the poisoning look like something else. An example would be an elderly person with heart and lung disease who dies in his sleep. In this case, the person's private physician would sign the death certificate as a natural cardiac death and, almost always, the ME will accept it. Why? Because there is an old adage in medicine that says: Common things occur commonly. Most people who die in this situation do indeed die from natural causes, so searching for something more sinister would be neither logical nor practical. If the ME accepted the private physician’s cause of death, no autopsy would be done, and no toxicological examinations would be undertaken. An overdose of Morphine or digitalis or arsenic or anything else would go undetected. 

Unless someone asked questions. Maybe a high-dollar inheritance or insurance policy is in play. If an inheritance, one family member could suspect another and ask questions. In the case of a large insurance policy, the insurance company would look under every stone before paying off the policy. Or your sleuth could have some reason to suspect that things are not as they seem. In any of these situations, the ME might be moved to open a file and investigate. 

But if your killer is clever, he might be able to keep the ME completely out of the picture or at least give him an easy answer for the cause of death. If no murder is suspected, he'll take the path of least resistance, which is also the cheapest route. Remember, he must live with and justify his budget annually. If he is wasteful, he'll be looking for a job. So, give him a cheap and easy out. Your sleuth will then have to battle the ME to get the case re-opened.

The second thing a clever poisoner can do is to use a poison that is not readily detectable and will slip through most drug screens. Toxicology testing follows a two-tiered approach. Screening Tests, which are easier, faster, and cheaper, are used to identify common classes of drugs such as narcotics or amphetamines. This only tells the ME and toxicologist that some type of narcotic or amphetamine is present, but not which one. Determining which one requires more sophisticated, time-consuming, and expensive Confirmatory Testing. And if the screening tests are normal, no further testing is warranted and the ME would not spend the time and money to go further down that road. 

Drug screens typically test for alcohol, narcotics, sedatives, marijuana, cocaine, amphetamines, and aspirin. Some screen for a few other classes. Once a member of a class is identified, then confirmatory testing will determine exactly which member of the class is present and in what amount. For example, if narcotic is found in the screen, further testing might show that the actual narcotic present is morphine. Or an amphetamine might be further analyzed, and this might show that methamphetamine is the culprit. 

Your poisoner could use a poison that would not be found in the typical screen. Things such as arsenic, selenium, and most plants (oleander, deadly nightshade, etc.) do not show up on the typical tox screen, and when the screen comes back negative, the ME might not go further. Why would he spend the time and money without a good reason? This is where your sleuth steps in to shake things up.

But, if a poison is suspected and if the funds and interest to pursue it are present, anything can be found in an intact corpse. Using gas chromatography in conjunction with either mass spectrometry (GS/MS) or infrared spectroscopy (GC/IR) will give a chemical fingerprint for any molecule. And since each molecule has its own structure and thus its own fingerprint, every compound can be distinguished from every other one.

To write a good mystery that will keep the reader guessing to the end, you must plot the nearly perfect murder. This way when your sleuth cracks the case, he or she will be a true hero. If poisoning is your killer’s chosen weapon, then use the above principles to make your plot as clever and convoluted as possible. Have your killer mask the death as natural or use some poison that is not readily detectable in screening tests and then your sleuth must be very clever to solve the case.

There are several sources for you to search out poisons and to discover how they act and how they are identified. Google, of course, and try plugging into your state poison control center. My books, Forensic For Dummies, Murder and Mayhem, and Forensics and Fiction cover a number of poisons. I also recommend Howdunnit: Book of Poisons by Serita Stevens and Anne Bannon from Writers’ Digest Books. It is a great resource for poisons of all types.

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DP Lyle Shane McKnight DP Lyle Shane McKnight

What if?: A Most Important Question 

Every author is asked where they get their ideas. This post explores how an idea transforms into a full story, starting with the crucial question: What if? It’s the foundation of every gripping narrative.

By DP Lyle 


Every author has been asked: Where do you get your ideas? The short answer is: Everywhere. Something you see or read germinates an idea, and a story unfolds. Sometimes the story comes together quickly, but most often weeks of building mental scenes and snippets of dialog, setting, and action must be waded through before pen meets paper. 

An overheard conversation might be the spark. Or a couple talking/arguing/laughing at a nearby restaurant table. Maybe an odd character strolling down the street. Perhaps an idea simply pops into your head from wherever those thoughts arise. 

Okay, so you have an idea. Now what? An idea isn’t a story. Ideas are a dime a dozen. They are literally everywhere. The key is to find an idea that can stand up through a 100,000-word manuscript. No small trick.

To do this, the original idea must be refined and fleshed out. An idea can become a scene, but to be a full-length novel it must evolve and expand. It must become a premise, or what many call “The Central Story Question.” It’s what the story is really about.

To become a premise, the original idea must ultimately lead to the question: What if? 

What if this happened? What if that person did this? What if that dude in the shabby clothes was actually a rogue undercover agent with a deadly agenda? What if the restaurant couple was planning a murder? What if that briefcase contained state secrets? Or an explosive device? Or a deadly virus?

From those two words--What if?--stories arise.

The power of your story’s What If? can’t be overestimated. If it is done correctly and not lost in the writing. A good What if? states the main character, the situation, the stakes, and, most importantly, the Central Story Question. 

It is the answering of this question that is the story.

Okay, so our restaurant couple is planning a murder. Who, what, when, where, and, most importantly, why? It’s always the why that makes a great story. Is it to get out of a messy marriage and save all that alimony money, or to cash in that million-dollar insurance policy, or to cover an embezzlement from a company they work for, or to seek revenge for some act? Even though the original idea was a couple planning a murder, each of these scenarios generates a different story. Each will lead your sleuth, who must solve the murder, into a different world.

What if a young couple witnesses a murder and in so doing put themselves in the cross hairs of a transnational criminal organization?

This is the What If? for my latest Cain/Harper thriller, TUNICA. 

The What If? should be stated in about 25 words or less. Because the What If? is brief, it’s often called the elevator pitch or the agent pitch. It communicates your story in the most efficient terms. We’ve all heard writers respond when asked what their story is about by saying things like, “Well, there’s this guy who lives on an island. And he hates the water. And a big shark is killing people and this is threatening to shut down the town’s beaches on a holiday weekend. And then there’s this other guy who is a shark expert and he has a really cool boat. Oh, I forgot, the first guy is the chief of police.” Yawn.

What if a hydrophobic, island-community police chief must go out on the water to kill a predatory shark to save the town’s summer economy and to prove his own self-worth?

What if an FBI trainee must exchange personal information with a sadistic serial killer in order to track another serial killer and save a Senator’s daughter?

What if the youngest son of a mafia family takes revenge on the men who shot his father and becomes the new godfather, losing his own soul in the process?

These are of course Jaws, Silence of the Lambs, and The Godfather, respectively. See how these What If?s reveal the protagonist and cleanly state the story premise? Read these books or watch the movies and you will see that each scene moves toward answering the story’s What If? Each of your scenes should, too. If not, consider cutting, or at least reworking, those that don’t.

Many authors consume weeks creating the What If? for their story. Constantly refining it, making it more on point. You should, too. It’s that important. It concisely states the Central Story Question.

Here’s a tip: When your What If? is completed to your satisfaction, print it out and tape it to your computer or the front of your writing pad so you will see it every time you sit down to write. Before writing each scene, read your What If? and ask yourself, “Does this scene help answer the Central Story Question?” If you do this, you will never lose sight of what your story is about. Particularly in the dreaded middle, where so many stories get lost in the jumble of character and backstory and cool dialog all the other stuff that goes into a manuscript. The What If? keeps you focused and on track.

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Steven Harms Shane McKnight Steven Harms Shane McKnight

The Writer’s Playbook: Interview Your Characters

Struggling with writer's block? Try the "Kohl method" of interviewing your characters with unexpected questions to discover new aspects of their personality and move your story forward.

By Steven Harms


To start, calculators down.

Now answer the following:
What is three times three?
Ten times seven?
Nine times two?
And, to finish this little exercise, what is eighty-five times forty-six? Take your time.

Hopefully you nailed the final answer. You may be asking what this has to do with being an author? Read on.

In the spring of 1985, I was two years into my first job at the Detroit Pistons. Around that same time, in my hometown of Milwaukee, Wisconsin something occurred that got my attention. The Milwaukee Bucks of the NBA had recently been purchased by Herb Kohl – I’ll get to him in a moment – and I felt the opportunity to return home was worth an inquiry. New ownership of a pro team generally comes with a slate of changes on the business side to align with a new owner’s vision and desire for how they want the place to operate. I wasn’t wrong. I sent a letter of inquiry to the president of business operations of the Milwaukee Bucks, not expecting a reply.

Two weeks later I received a call from John Steinmiller, introducing himself and asking that I come to Milwaukee for an interview. The role was a new position, and the person they were seeking would be responsible for building the sales team and crafting the external sales strategy.

I was flown in the following week and met with John. Our discussion went well, and I was excited to put it mildly. The opportunity would advance my career to the next level. As John wrapped our interview, he informed me that the new owner, Herb Kohl, would also like to meet with me one-on-one.

Who’s Herb Kohl? Perhaps you’ve shopped at Kohl’s. That was Herb’s family business, begun by his father in 1924. Kohl’s began as a grocery chain in the Milwaukee area before adding department stores beginning in 1962, eventually selling it all off in 1979. Herb Kohl purchased the Bucks in 1985 to prevent the team from exiting Milwaukee, in line with his community mindedness, which eventually led to him becoming a U.S. Senator, representing Wisconsin for twenty-four years. That’s the man I now sat across from in his spacious office at a top floor of Milwaukee’s tallest building.

The interview with him was straightforward – my background, schooling, sales experience with the Detroit Pistons, family, goals, and a few other traditional interview topics. Herb was a soft-spoken person, palpably gracious, and he made me comfortable as we chatted. Somewhere amid that interview, completely out of the blue, he asked me that final math question at the top of this article. Stone cold. No pivot. I can’t recall the exact digits, but you get the idea. To this day, I remember Herb said, “Take your time.” It was a jolt. I recall thinking that I was about to blow the interview and wouldn’t get the job. But I figured out quickly how to process the problem and answered it correctly. He then tossed me two more of similar nature. I passed all three. In the end, I landed the job.

My length of service with the Bucks lasted four years before I moved to New York City for my next opportunity. In hindsight, I wish I had taken a moment during my time with the Bucks to ask Herb why he threw those math problems at me. I’m convinced he did so to see how I process information and how I manage myself in a stressful situation. I just never asked. I think I know the answer, at least in part, which aligns with the task we have in creating our characters and developing them.  

Every good author understands that characters tell the author what to write, not the other way around. We’re responsible for bringing the people in our stories to life, intently listening to each, being thoughtful of their backstory, and abiding by who they are as a character. Their dialogue and actions drive the plot. How those are handled by an author is critical to maintaining a compelling, authentic story.

But what happens when a scene or chapter or subplot just won’t materialize, better known as writer’s block? All authors experience that moment, some less than others, but it’s unavoidable. It will happen, probably multiple times in the process of producing a manuscript. Successfully dealing with the problem opens the door to kickstart the interrupted creative process. There are many methods, but taking a cue from Herb Kohl, consider copying his technique.

Have a conversation with the characters on what they’re thinking. Throw them a wildly incongruent question of fact or importance that is unconnected to the story and see how they respond. If their answer misses the mark, that’s alright. Now you know. If they arrive at a plausible, reasonable answer, now you know that as well. If they hem and haw and sweat, tell them to take their time and only move on after they’ve answered. That’s also informative. You now perceive facets of them you hadn’t known, which may be a key ingredient in unblocking yourself and taking your story to a higher level.

Next time you’re at a Kohl’s, or drive by one, or see one of their advertisements, think back to this article and consider the “Kohl method” of interviewing a character(s) to handle current or future writing blocks. He or she may be able to figure out the “math question” you pose. Or maybe not. Either way their strengths, weaknesses, make-up, countenance, and other previously unrevealed attributes will come to the fore.

Just one rule, though. No calculators allowed.

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Paula Messina Shane McKnight Paula Messina Shane McKnight

You Want Me to Spend Time with You?

For a character to keep readers invested, flaws are fine as long as they're presented effectively. This article explores how character development, contrasts, and redeeming qualities can make even the most unlikable characters worth following to the end.

By Paula Messina


We all have different measures for what keep us reading. One of mine is characters I’m willing to live with all the way to the end. The gift of a mystery got me thinking about this. Why do some characters meet my requirement and others fail?

The novel looked promising. The author had won a prestigious award. The main character is an archaeologist. I enjoy books that involve an expertise, especially one I’m not schooled in. Alas, my interest dwindled quickly.

The story is told through the main character’s viewpoint. She is miserable and self-loathing because of her weight. This was not a good sign, but I read on. Soon enough a detective needs her help on a murder case. He comes not with hat in hand. Rather, he’s downright nasty. Not only is the detective as off-putting as the main character, his approach is irrational. The characters have no history together. His unprofessional behavior is inexplicable, even cause for termination. Didn’t he learn at his mother’s knee you catch more flies with honey than vinegar?

Actually, he was terminated. I stopped reading the book.

For me to sustain interest, I don’t demand that the characters be Mother Teresa incarnate or a Nobel Peace Prize winner or even a Boy Scout rescuing abandoned dogs. It’s those one-note grumpy characters I can live without. 

I’m not alone in this. After I closed that book, I read the online reviews. I have plenty of company. The negative reviews essentially said the same thing: I don’t want to waste my time on these characters.

It’s next to impossible to imagine anyone more dislikable than Ebenezer Scrooge. Dickens is emphatic that absolutely everyone avoids him. “Even the blind men’s dogs appeared to know him; and, when they saw him coming on, would tug their owners into doorways and up courts; and then would wag their tails as though they said, ‘No eye at all is better than an evil eye, dark master!’”

And yet Scrooge is one of the most enduring and, dare I say, beloved characters in English literature. Ebenezer is proof that flaws are fine. It’s how flaws are presented that makes all the difference. Characters need not be perfect. Indeed, they shouldn’t be.

Dickens pulls the reader into A Christmas Carol by raising questions. Who is Marley and why should we care that he died? Why was Scrooge “his sole executor, his sole administrator, his sole assign, his sole residuary legatee, his sole friend, and sole mourner.”?

Dickens quickly establishes Scrooge’s wretched personality. No reader would invite Ebenezer over to watch the Super Bowl, at least not until the three Ghosts of Christmas get through with him. Dicken’s delicious descriptions keep us curious about how one being could be so miserable and disliked, but delicious descriptions only satisfy for so long. Dickens could have easily pushed Scrooge into an unbearable, unreadable character.

Yet Ebenezer Scrooge endures. Why?

The answer is simple. Scrooge doesn’t tell the story. An intimate, chatty, gossipy narrator does. If Scrooge told A Christmas Carol, it is highly doubtful even the inestimable Dickens could keep readers turning the pages for one hundred eighty years.

Arthur Conan Doyle and Rex Stout used the same technique for the odd genius Sherlock Holmes and the often belligerent but brilliant Nero Wolfe. We see Holmes and Wolfe through the eyes of their friends, and because Watson and Goodwin find redeeming social value in Sherlock and Wolfe, the reader does as well.

It’s no accident that Dr. John Watson is a cheerful, friendly character, or that Archie Goodwin is only a few IQ points short of Wolfe’s genius. Archie is wittier than Wolfe, likes women, and is a great dancer. Our view of Sherlock and Nero is filtered through these immensely enjoyable narrators, and we’re willing to stick around until the end.

A narrator isn’t the only technique to make an unpleasant character palatable. We often describe our lives in absolute terms. I’ll never be anything than an utter failure. My husband never compliments me. My mother never has a kind word for anyone. There’s a name for this kind of thinking: cognitive distortion.

We humans are not a never-ending one note, miserable or ecstatic. Even in the worst of times, we laugh at a good joke, make goo-goo eyes at an infant, and enjoy the warm sun on our skin. It’s impossible to be miserable all the time, just as it’s impossible to be endlessly upbeat.

Humans experience ups and downs throughout a day, a year, a lifetime. Characters do as well. Good characters are complex. They enjoy life one minute and complain in the next. They lament about their weight, then promise to diet tomorrow.

In the mystery mentioned, a little levity, for example, would have made the character’s self-loathing tolerable. An explanation and an apology would have made the detective’s initial bad impression understandable and relatable. In other words, mitigating circumstances make an unpleasant character more lifelike, but even mitigating circumstances only carry a reader so far. 

Sherlock’s genius makes him impatient with lesser mortals. Wolfe has a dark past that is never explained. It possibly involves a bitter betrayal by a woman. Dickens shows us Scrooge’s descent into a spiritual wasteland through a series of flashbacks while also showing Scrooge’s journey to reclaim his soul. It is those flashbacks that make his redemption on Christmas Eve believable. His goodness was always there to be brought to life. We know in our hearts that Ebenezer Scrooge does become “as good a friend, as good a master, and as good a man, as the good old city knew, or any other good old city, town, or borough, in the good old world.”

It’s not flaws that are off-putting. A character without a flaw is malformed. It’s how those flaws and foibles are presented that makes the difference. A main character can be stubborn and uncooperative. Supporting characters can goad the protagonist into a better disposition. Archie Goodwin is a master at this. Introduce a humorless character to a cutup. Dr. Watson on the page isn’t the bumbling Nigel Bruce, but he does lighten Holmes’ intensity. A dour woman populating pages needs to meet a ray of sunshine. Conversely, that main character who insists on imitating Pollyanna is just waiting for someone to burst her bubble.

Contrasts work wonders. Characters bring out different aspects of the main character. Best-selling author Barbara A. Shapiro says different friends bring out different aspects of our personalities.

Think about it. You discuss politics and solve the world’s problems with one friend. You’re a veritable joke machine with another, and a third has you discussing how to grow mushrooms and make kimchi and sauerkraut. Scrooge interacts differently with Bob Cratchit than he does with his nephew Fred. Scrooge moves from disbelief, to insolence, fear, and finally to submission as he travels with each ghost.

This works both ways. No human is always bubbly and positive. Characters aren’t either. What my friend Marilyn says of life is also true of fiction. “If you don’t have a problem now, wait two weeks.”

In the novel I’m writing, Donatello, my main character, is essentially a good guy, but he vents his fury on his parish priest. The priest deserves the drubbing, but Donatello believes it’s a sin to scream at a priest. He screams anyway. Donatello would be a weak character if he ignored the priest’s nastiness.

Donatello’s anger serves another purpose. It displays Donatello’s determination to reclaim his life after an accident robs him of his dream to pitch pro ball. Donatello’s anger says he’s not giving up. No one’s pushing him around, not even his parish priest. This anger intensifies Donatello’s commitment to find his sister’s murderer.

When I pick up something to read, I want to be carried along in a story filled with characters I’d invite to share my life for a while. They can be a pompous Sherlock, a ton of immovable flesh a la Wolfe, or a Scrooge so nasty even dogs avoid him. But I only keep reading if those negative traits are balanced by positive ones. In short, for this reader, how a writer presents his characters is vitally important. 

As for the kvetchers, the malcontents, the one-note nasties, I’d rather not even open the book.


Paula Messina lives near America’s first public beach. When she isn’t sloshing barefoot through the Atlantic, she’s writing short stories and essays. Her humorous caper, “Which Way New England?” appears in Wolfsbane, Best New England Crime Stories 2023. “Science for the Senses,” an essay, is in issue 7 of Indelible Literary and Arts Journal. You can listen to her reading works in the public domain at librivox.org.

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